Comment: Call For More Information On Age-Related Memory Loss

Comment: Call For More Information On Age-Related Memory Loss




Comment From Mary:

Please keep me updated on all this information. This information can help so many people I know.

Please send me all the lab tests and other tests so I can make these recommendations. So many people are so stressed they they are in early stages if Alsheimers. I thing it is party

Just memory lost due to age

Let me know what tests need to be taken to find out. Please also what you would suggest to those to keep their memory as long as possible.
Thank you for your knowledge and time. This is a very important to so many people.


This is great news and reason for hope that age does not cause Alzheimer’s disease. The authors state, Alzheimer’s is distinct from age related memory loss, which is reversible.  This is preliminary, and already successful screening therapies that reverse age related memory loss in  rodents found.

Keep in mind the only finding was a suggestion. In addition, the study was post-mortem, performed on brains thought to have age-related dementia.

Study found one of unknown number of proteins involved in age-related dementia. Good news is multiple potential therapeutic interventions.

Hippocampus is an important area for memory, learning, and even depression. Age related dementia is a disorder associated with dysfunction in a sub-region of the hippocampus also affected by Alzheimer’s disease.

Alzheimer’s causes loss of neurons in the entorhinal cortex (EC), a region of the brain that provides major input neuron pathways to the hippocampus. This input affects the sub-region of the hippocampus affected by age-related dementia, dentate gyrus

The above is a nice explanation for the similarity of symptoms —early memory loss.    This study is compelling evidence that not all loss of memory is Alzheimer’s disease.  Age-related memory loss localized to dysfunctions in the sub-region of the hippocampus, dentate gyrus is reversible.  Evidently, researchers identified many effective SCREENING therapeutic interventions in RODENTS for age related dementia one of them is RbAp48.

Caution : Questions Remain on How to apply this information clinically?

1. How to distinguish clinically between age-related memory loss and early Alzheimer’s disease in humans remains unclear?
The article did not perform functional MRIs on humans [as this was a post-mortem test tube and animal study]

Will Early Alzheimer’s and age-related memory loss have similar functional MRI patterns in the initial stages of Alzheimer’s?


Are protein abnormalities, such as  RbAp48, in age-related memory loss unique  to this type of memory loss?  Are these proteins produced in the dentate gyrus  associated with other  pathologies,  starting with  diseases noted post-mortem?

2. What are the toxicities of RbAp48? As this was a post-mortem study toxic effects on humans are unknown; however, what are the toxicities in rodents?  These proteins produce other effects, what are the toxic effects of these proteins?

Below is a copy of the Phases of Clinical Trials

Found at: – Clinical Trial Phases (There are some variations)

FAQ – Clinical Trial Phases

Question: What are clinical trial phases?

Clinical trials are conducted in a series of steps, called phases – each phase is designed to answer a separate research question.

  • Phase I: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
  • Phase II: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
  • Phase III: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
  • Phase IV: Studies are done after the drug or treatment has been marketed to gather information on the drug’s effect in various populations and any side effects associated with long-term use.

Additional Resource Information on clinical trials can be found at


This study appears to be a pre-clinical study. Preclinical studies are animal studies or test tube studies intended to show efficacy, toxicity, and pharmacokinetics using a wide range of dosages.

In addition, the article’s  discussion of clinical efficacy of RbAp48 in age related dementia suggested the introduction of new drugs aimed at age-related memory loss.

Please remember the underlying thesis for these drugs.   Look for  Toxicity and Pharmacokinetics of RbAp48 and other similar drugs to be used for age-related memory loss.

Pharmacokinetics are the effects on a living human body of a drug from the moment of ingestion to elimination of the drug. Hopefully, other studies will follow that shed light on toxicity and pharmacokinetics before RbAp48 is used on healthy human subjects.

{The findings of many drug studies are not accessible to the public partly because subscription fees, unreasonably high, prevent access. }

In summary, pre-clinical studies form the basis of Phase 1 studies, performed on Healthy volunteers.

This study will guide future studies and give hope that not all memory loss is Alzheimer’s disease– in other words, progression to severe disabilities and death are not inevitable.

Also, this study informs radiologists, neurologists, internists and other physicians to look more closely at regions of the hippocampus, in particular the dentate gyrus sub-region  and the entorhinal cortex region of the brain, in diagnosing memory loss.

There is hope for those with age-related memory loss.


Sources Mentioned:




2.  Hippocampus

3. – Clinical Trial Phases

4. FAQ: – What is is an easy-to-use Web site that provides regularly updated information about federally and privately supported clinical trials. You can find specific clinical trials for a wide range of diseases and conditions.
Each record provided in lists the following:
• Disease or condition and experimental treatments studied
• Title, description, and design of study
• Requirements for participation
• Locations where the study is available
• Contact information
• Links to relevant information at other health Web sites, such MedlinePlus and PubMed
Additional Resource Information on clinical trials can be found at
Related Questions: questions


Author: Angela Grant

Angela Grant is a medical doctor. For 22 years, she practiced emergency medicine and internal medicine. She studied for one year at Harvard T. H Chan School Of Public Health. She writes about culture, race, and health.

56 thoughts on “Comment: Call For More Information On Age-Related Memory Loss

  1. Please keep me updated on all this information. This information can help so many people I know.
    Please send me all the lab tests and other tests so I can make these recommendations. So many people are so stressed they they are in early stages if Alsheimers. I thing it is party
    Just memory lost due to age
    Let me know what tests need to be taken to find out. Please also what you would suggest to those to keep their memory as long as possible.
    Thank you for your knowledge and time. This is a very important to so many people.

      1. Can I add a bit of information? I have a study research link to the 60-Minutes on which this new research appeared. From there additional links can be followed. The story goes like this: there is a senior center between Los Angeles and San Diego that people joined over 30 years ago–and still do to spend their last years full of activity and no worries. It is an expensive place, not a nursing home.

        UCI researchers have been following seniors there for 30 years annually and put them through a battery of tests and after death all of these seniors who participated in the study over 30 years have donated their brains for further research. What they found will shake the scientific circles on ageing and brain/mental health and dementia. Here is what they found in brief:

        1) People showing strong dementia in life may or may not have had any plaque in the brain or changes in the brain thus brain atrophy and plaques may not be connected to dementia

        2) People who showed absolutely no signs of dementia may or may not have had atrophy and plaque build up in the brain–further proof that neither plaque nor atrophy has anything to do with causing dementia or even being part of it

        3) Contrary to popular belief, those with higher than what we consider normal lived longer consistently! Those with normal BP died in the 80’s and those with higher BP lived into their 90’s and many into their 100’s and many still alive, walking 3-4 miles a day at age 100.

        This blood pressure increase benefit I can explain from the perspective of the brain: more blood to the brain brings more oxygen and nutrition to the brain so ATP function is enhanced. People who had lower BP had less blood flowing to their heads and they perhaps were more likely to have dementia as a result.

        There is much more research that needs to be done but their findings have shaken up the research industry on dementia and aging. You can find the original program here: and go from there. They also have links to publications: and here is the research link to UCI:

        Hope this helps!

        1. Thanks..I’ll check the links out. Mary S. is interested in the info….I will also check out the NIH site which I use to do regularly.

          .You are correct the radiographic findings do not always correlate with the clinical findings.

          1. One more thing, just so you know about NIH:

            They have Montelukast = Montelukast Sodium on one page and not on another. I sent them an email that they are wrong here and right there and requested corrections. I also called Merk and told them that unless this gets corrected, they will be sued for “bad drug” that they have nothing to do with. They have jumped into action.

            NIH is only as reliable as the people who post to NIH. Medscape is the same. The only place that got Montelukast versus Montelukast Sodium right is the FDA. So when you read something on NIH, use caution in the interpretation…

            1. Angela, if you can’t trust info from the NIH you can’t trust any information. The last point I agree wholeheartedly: you cannot trust ANY information without doing your own research

    1. You have to be kidding. Those links are more technical. And here I thought I broke the article down a bit….I will keep trying…perhaps the use of cliches might help.

      What is technical in the above explanation?

      The article is well written and my comment meant to respond to Mary’s questions while providing a foundation to process to data , particularly scientific data. Critical thinking is important and that is what the above response attempted.

      1. So here I stand now, corrected, disillusioned, rubbing the tears from my eyes, waving to humanity in a last farewell, having thought most of them knew and understood at least a little bit of what was going on in the dungeons of their paid for labs, universities, fortresses of science, and what was lurking and lingering in the hard- and software of their digital toys. Aw, how harsh my life has become now. Better I pray for some memory loss this very minute, to soften my unbearable pain.

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